Home / The Curbsiders Internal Medicine Podcast / #508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

#508: ASCVD Risk & Lipids Update! PREVENT, ApoB, Lp(a) + Next-Gen Therapies

The Curbsiders Internal Medicine Podcast

Dec 15, 2025

1h 35m

Description

Master cardiovascular disease prevention! Learn how to apply the new PREVENT risk calculator, use the CPR framework for risk reclassification, and interpret ApoB and Lp(a) in modern lipid management. We’re joined by Dr. Laurence Sperling to break down what’s new in ASCVD risk assessment and prevention.

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Show Segments

Intro

Case 1 from Kashlak

Risk assessment framework

ApoB and Non-HDL cholesterol

Lipoprotein(a) and its importance

The PREVENT risk score and its implications

Statins and other lipid lowering therapies

The role of diet and lifestyle in lipid management

Case 2 from Kashlak

Familial Hypercholesterolemia diagnosis and management

Key takeaways

Outro

Credits

Producer, Writer, Shownotes, Infographic, and Cover art: Ben Furman, MPH

Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP

Reviewer: Leah Witt, MD

Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP

Technical Production: PodPaste

Guest: Laurence Sperling, MD

Disclosures

Dr. Sperling reports no relevant financial disclosures. The Curbsiders report no relevant financial disclosures.

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