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Jan 09 2026 This Week in Cardiology
New Jan 09, 2026 28 min

Jan 09 2026 This Week in Cardiology

The limits of knowing coronary artery disease anatomy, fish oil and AF risk, a new drug for PSVT, and maybe I was wrong about a drug for AF conversion (the RAFF4 trial). These are the topics John M...

Dec 19 2025 This Week in Cardiology
Dec 19, 2025 35 min

Dec 19 2025 This Week in Cardiology

The MI paradox of risk scores, the CELEBRATE trial of a new subcutaneous glycoprotein IIb/IIIA inhibitor (with its funny endpoint), the SURPASS CVOT trial, and the bad story of andexanet alfa are t...

Dec 12 2025 This Week in Cardiology
Dec 12, 2025 27 min

Dec 12 2025 This Week in Cardiology

An elegant study in post-TAVI atrioventricular block, a PSA for my structural colleagues, revascularization in women, and a CTO PCI trial are the topics John Mandrola, MD, discusses in this week's ...

Dec 05 2025 This Week in Cardiology
Dec 05, 2025 29 min

Dec 05 2025 This Week in Cardiology

Less is more after PCI, the TARGET-FIRST trial, a negative blood pressure trial that is actually positive, aspirin vs OAC for bleeding, AEDs, and Factor XI is not dead yet are the topics discussed ...

Nov 21 2025 This Week in Cardiology
Nov 21, 2025 29 min

Nov 21 2025 This Week in Cardiology

Listener feedback, huge news in the world of carotid disease with the CREST-2 publication, prasugrel beats ticagrelor again, and a big coffee trial are the topics John Mandrola, MD, discusses in th...

Nov 14 2025 This Week in Cardiology
Nov 14, 2025 36 min

Nov 14 2025 This Week in Cardiology

Listener feedback on the PISCES trial, AHA news (including a big PCSK9i trial), beta-blockers post MI, LAAC, and post-AF ablation OAC use are the topics John Mandrola, MD, discusses in this week's ...

Nov 07, 2025 This Week in Cardiology
Nov 07, 2025 32 min

Nov 07, 2025 This Week in Cardiology

Listener feedback on non-culprit PCI in STEMI, a major cardiac result in patients on hemodialysis, news on GLP-1 agonists, a dubious stroke trial, and an AHA preview are the topics John Mandrola, M...

Oct 31 2025 This Week in Cardiology
Oct 31, 2025 31 min

Oct 31 2025 This Week in Cardiology

Four pillars of cardiology today, stable coronary artery disease, severe aortic stenosis, the evaluation of chest pain, and best therapies for atrial fibrillation are the topics John Mandrola, MD, ...

Oct 24 2025 This Week in Cardiology
Oct 24, 2025 30 min

Oct 24 2025 This Week in Cardiology

The PREVENT score in hypertension, GLP-1 mechanism of action in cardiovascular disease, CAD type and statin benefit, and the problem with hospitalization endpoints in HF trials are the topics John ...

Oct 17 2025 This Week in Cardiology
Oct 17, 2025 32 min

Oct 17 2025 This Week in Cardiology

Another knock against the antiplatelet/anticoagulant combo, polypills in HF, the physical exam of the future, and the problem of underpowered trials that even Bayesian analyses cannot rescue are th...

Oct 10 2025 This Week in Cardiology
Oct 10, 2025 26 min

Oct 10 2025 This Week in Cardiology

GLP-1 use in HFrEF, left atrial posterior wall isolation during AF ablation, peri-device leaks for LAAO, new findings in post-cardiac surgery AF, and imaging before AF ablation are the topics John ...

Oct 03 2025 This Week in Cardiology
Oct 03, 2025 26 min

Oct 03 2025 This Week in Cardiology

Two great stories of translation science leading to beneficial drugs in terrible diseases of the heart and the Sisyphean task of predicting the need for pacing after TAVI are the topics John Mandro...

Sep 26 2025 This Week in Cardiology
Sep 26, 2025 22 min

Sep 26 2025 This Week in Cardiology

A bold trial in valvular heart disease, a CV prevention trial whose message is humility, VTE dogma challenged, more news on oral GLP-1 agonists, and a few public service announcements are the topic...

Sep 19 2025 This Week in Cardiology
Sep 19, 2025 33 min

Sep 19 2025 This Week in Cardiology

More trials at ESC, including PARACHUTE HF, DAPA ACT HF-TIMI 68, AMALFI, and a super-interesting modeling study of when to start oral anticoagulants in AF, are the topics John Mandrola, MD, discuss...

Sep 12 2025 This Week in Cardiology
Sep 12, 2025 31 min

Sep 12 2025 This Week in Cardiology

More from ESC including: Valvular HD guidelines, a new drug class for HTN, myosin inhibition in HCM, vericiguat, and digoxin are the topic discussed by John Mandrola, MD. This podcast is intended f...

Sep 05 2025 This Week in Cardiology
Sep 05, 2025 38 min

Sep 05 2025 This Week in Cardiology

The big beta-blocker story from ESC, dual pathway therapy with aspirin and OAC, stopping OAC after successful AF ablation, and DANCAVAS II trial are the topics John Mandrola, MD, discusses on this ...

Aug 29 2025 This Week in Cardiology
Aug 29, 2025 34 min

Aug 29 2025 This Week in Cardiology

CAC 0 takes a gut punch, ICD therapies cannot be surrogates for benefit, and two important trials from ESC are the topics John Mandrola, MD, discusses in this week's podcast. This podcast is intend...

Aug 22 2025 This Week in Cardiology
Aug 22, 2025 26 min

Aug 22 2025 This Week in Cardiology

John Mandrola discusses conduction system pacing vs standard pacing, withdrawing HF meds when AF is corrected and patient selection in LAAO. This podcast is intended for healthcare professiona...

Aug 15 2025 This Week in Cardiology
Aug 15, 2025 23 min

Aug 15 2025 This Week in Cardiology

Big new hypertension guidelines, ultraprocessed foods, coronary sinus reduction and evidence-based medicine, and more news on pulsed field ablation for atrial fibrillation are the topics John Mandr...

Aug 08 2025 This Week in Cardiology
Aug 08, 2025 31 min

Aug 08 2025 This Week in Cardiology

Listener feedback on SURPASS CVOT, AF ablation and the limits of meta-analyses, a Watchman alert from FDA, and oral anticoagulation choices in elderly patients are discussed by John Mandola, MD, in...